Abstract: This outlook paper focuses on micelles formed by introducing more than one kind of polymer blocks with different properties into the same micelle. It can be a plausible candidate that is capable of tuning the resulting properties and meeting various requirements for specific applications. Many parameters may anticipate to affect the formation of stable mixed micelles. Several typical forming types and structures are discussed. There are micelles with different internal structure such as micelles with a heterogeneous core and a homogeneous corona or micelles with a homogeneous core and a mixed corona or core-shell-corona micelles. They possess characteristic stability，drug delivery and stimuli-responsibility. Finally，potential applications of these objects are discussed. Composite structures are expected to realize synergistic drug loading，channel release and drug controlled release. It will play a more important role in the field of drug controlled release.

Key words: complex micelles, comicellization, mixed micelles

摘要： 概述了采用两种不同共聚物共混的方式制备多组分复合胶束的方法。共混不仅引入了新的胶束组分，还增加了胶束的可调节参数，由此得到的复合胶束具有不同于之前单一组分胶束的特殊结构。复合胶束的功能结构更富于变化，可以适应更多的功能需求。复合胶束的形成受到很多方面的影响，本文介绍了几种具有代表性的复合胶束结构的形成方式和结构特征，如复合核、复合冠、核-壳-冠胶束结构等。它们分别具有独特的稳定性、药物控释性能和刺激响应性。展望了这些具有新颖胶束结构的复合胶束可能在药物传输体系中具有的新功能。复合结构有望实现协同载药、胶束通道释药和药物的可控释放等，将在药物控制释放领域发挥巨大的作用。

关键词: 复合胶束, 共胶束化, 共混